Methylphenidate HCl

A to Z Drug Facts

Methylphenidate HCl

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(meth-ill-FEN-ih-date HIGH-droe-KLOR-ide)
Methylphenidate HCl
Tablets: 5 mg, 10 mg, 20 mg
Tablets, extended-release: 20 mg
Ritalin
Tablets: 5 mg, 10 mg, 20 mg
Metadate ER
Tablets, extended-release: 10 mg, 20 mg
Methylin
Tablets: 5 mg, 10 mg, 20 mg
Methylin ER
Tablets, extended-release: 10 mg, 20 mg
Concerta
Tablets, extended-release: 18 mg, 27 mg, 36 mg, 54 mg
Ritalin-SR
Tablets, sustained-release: 20 mg
Metadate CD
Capsules, immediate- and extended-release: 20 mg
Ritalin LA
Capsules, extended-release: 20 mg, 30 mg, 40 mg
PMS-Methylphenidate
Class: Psychotherapeutic/CNS stimulant

 Action Acts as mild cortical stimulant with CNS action; exact mechanism of action unknown.

 Indications Treatment of attention-deficit hyperactivity disorder (ADHD); treatment of narcolepsy.

 Contraindications Marked anxiety, agitation, and tension; glaucoma; motor tics; family history or diagnosis of Tourette syndrome; concurrent treatment with MAO inhibitors and within a minimum of 14 days following discontinuation of a MAO inhibitor.

 Route/Dosage

ADULTS: PO 10 to 60 mg/day in 2 to 3 divided doses. CHILDREN 6 YR AND OLDER: PO 5 mg before breakfast and lunch initially; increase by increments of 5 to 10 mg/wk up to 60 mg/day. Give sustained-release (SR) tablets at 8-hr intervals. ADULTS AND CHILDREN (6 YR AND OLDER): PO Concerta: In patients new to methylphenidate, start with 18 mg once daily in the morning, then adjust dose in 18 mg increments at weekly intervals (max, 54 mg once daily in the morning). In patients being converted from methylphenidate regimens to Concerta, start with 18 mg of Concerta every morning in patients receiving methylphenidate 5 mg bid or tid or 20 mg SR; start with 36 mg of Concerta every morning in patients receiving methylphenidate 10 mg bid or tid or 40 mg SR; start with 54 mg of Concerta every morning for patients receiving methylphenidate 15 mg bid or tid or 60 mg SR. The dose of Concerta may be adjusted in 18 mg increments at weekly intervals (max, 54 mg once daily in the morning). Metadate CD: Start with 20 mg once daily in the morning before breakfast, then adjust dose in 20 mg increments at weekly intervals (max, 60 mg once daily in the morning). Ritalin LA: Start with 20 mg once daily in the morning, then adjust dose in 10 mg increments at weekly intervals (max, 60 mg once daily in the morning).

 Interactions

Anticonvulsants (eg, phenobarbital, phenytoin, primidone), selective serotonin reuptake inhibitors (eg, fluoxetine), tricyclic antidepressants (eg, imipramine): Plasma levels of these agents may be increased by methylphenidate, increasing the risk of side effects. Guanethidine: The antihypertensive effects of guanethidine may be decreased. MAO inhibitors (eg, phenelzine): Because of the risk of hypertensive crisis, methylphenidate is contraindicated in patients receiving MAO inhibitors and for a minimum of 14 days after discontinuation of a MAO inhibitor.

 Lab Test Interferences None well documented.

 Adverse Reactions

CV: Changes in pulse and BP; tachycardia; angina; cardiac arrhythmias; palpitations. CNS: Nervousness; insomnia; dizziness; headache; dyskinesias; drowsiness; convulsions; toxic psychosis. EENT: Blurred vision. GI: Anorexia; nausea; abdominal pain; weight loss during prolonged therapy. HEMA: Leukopenia; anemia. OTHER: Hypersensitivity reactions (eg, rash, itching, fever, joint pain, exfoliative dermatitis, erythema multiforme, thrombocytopenia purpura).

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Do not give to children less than 6 yr because safety and efficacy not established. Carefully monitor children on long-term therapy, especially for growth in height and weight gain. Dependence: Chronic use may lead to tolerance, psychological dependence, and abnormal behavior. Use with caution in patients with history of drug abuse. Monitor withdrawal from drug therapy for symptoms that can include severe depression. Hypertension: Use drug with caution; monitor BP. Seizure disorders: Drug may lower seizure threshold in susceptible patients. Safe concomitant use with anticonvulsants is not established. If seizures occur, notify health care provider and consider withholding drug. Depression/Fatigue: Do not use to treat severe depression or normal fatigue. GI obstruction: Because Concerta tablet is nondeformable and does not change shape in the GI tract, do not administer to patients with pre-existing severe GI narrowing. Psychosis: Symptoms of behavior disturbances and thought disorder may be exacerbated.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
  Vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions, euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, dry mucous membranes

 Patient/Family Education

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Copyright
© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts